Difference between revisions of "20.109(F20):Journal club presentation"

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''' ''P. falciparum'' biology'''
 
''' ''P. falciparum'' biology'''
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#Garten, M., ''et. al.'' "[[Media:Garten EXP2 is a nutrient-permeable channel.pdf|EXP2 is a nutrient-permeable channel in the vacuolar membrane of ''Plasmodium'' and is essential for protein export via PTEX.]]" (2018) Nature Microbiology. 3:1090-1098.
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#Walszak, M., ''et. al.'' "[[Media:Walczak ATG8 is essential specifcally for an autophagy.pdf|ATG8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites.]]" (2018) mBio. 9:e02021-17.
  
 
'''Malaria drug discovery'''
 
'''Malaria drug discovery'''
  
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#Istvan ''et. al.'' "[[Media:Istvan Plasmodium Niemann-Pick type C1.pdf|''Plasmodium'' Niemann-Pick type C1-related protein is a druggable target reguired for parasite membrane homeostasis.]]" (2019) eLife. 8:e40529.  
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#Istvan, E., ''et. al.'' "[[Media:Istvan Plasmodium Niemann-Pick type C1.pdf|''Plasmodium'' Niemann-Pick type C1-related protein is a druggable target reguired for parasite membrane homeostasis.]]" (2019) eLife. 8:e40529.  
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#Nasamu, A., ''et. al.'' "[[Media:Armiyaw Plasmepsins IX and X.pdf|Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress adn invasion.]]" (2017) Science. 358:518-522.
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#Vanaerschot, M., ''et. al.'' "[[Media:Vanaerschot Inhibition of resistance-refractory.pdf| Inhibition of resistance-refractory ''P. falciparum'' kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity.]]" (2020) Cell Chemical Biology. 27:806-816.
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Brill, E. et al. “Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer.” (2017) Oncotarget. PMID:29158830
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Revision as of 00:11, 25 July 2020

20.109(F20): Laboratory Fundamentals of Biological Engineering

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Fall 2020 schedule        FYI        Assignments        Homework        Communication |        Accessibility

       M1: Genomic instability        M2: Drug discovery        M3: Metabolic engineering       


FIND ARTICLES FOR CATEGORIES: MALARIA BIOLOGY, SMM STUDIES, DRUG DISCOVERY RESEARCH

P. falciparum biology

  1. Garten, M., et. al. "EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX." (2018) Nature Microbiology. 3:1090-1098.
  2. Walszak, M., et. al. "ATG8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites." (2018) mBio. 9:e02021-17.

Malaria drug discovery

  1. Istvan, E., et. al. "Plasmodium Niemann-Pick type C1-related protein is a druggable target reguired for parasite membrane homeostasis." (2019) eLife. 8:e40529.
  2. Nasamu, A., et. al. "Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress adn invasion." (2017) Science. 358:518-522.
  3. Vanaerschot, M., et. al. " Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity." (2020) Cell Chemical Biology. 27:806-816.
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