20.109(F20):Journal club presentation

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20.109(F20): Laboratory Fundamentals of Biological Engineering

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Fall 2020 schedule        FYI        Assignments        Homework        Communication |        Accessibility

       M1: Genomic instability        M2: Drug discovery        M3: Metabolic engineering       


FIND ARTICLES FOR CATEGORIES: MALARIA BIOLOGY, SMM STUDIES, DRUG DISCOVERY RESEARCH

P. falciparum biology

  1. Garten, M., et. al. "EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX." (2018) Nature Microbiology. 3:1090-1098.
  2. Walszak, M., et. al. "ATG8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites." (2018) mBio. 9:e02021-17.

Malaria drug discovery

  1. Istvan, E., et. al. "Plasmodium Niemann-Pick type C1-related protein is a druggable target reguired for parasite membrane homeostasis." (2019) eLife. 8:e40529.
  2. Nasamu, A., et. al. "Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress adn invasion." (2017) Science. 358:518-522.
  3. Vanaerschot, M., et. al. " Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity." (2020) Cell Chemical Biology. 27:806-816.
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