Difference between revisions of "20.109(F20):M2D7"

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(Protocols)
(Part X: Design experiments to test putative small molecule binders)
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<font color =  #4a9152 >'''In your laboratory notebook,'''</font color> complete the following:
 
<font color =  #4a9152 >'''In your laboratory notebook,'''</font color> complete the following:
 +
 +
*Consider aspects of the experimental approach that could be improved.
 +
**What steps might you do differently to improve the results?
 
*Consider two potential next step experiments that you might perform to test putative small molecule binders identified from the SMM screen.  For each experiment:
 
*Consider two potential next step experiments that you might perform to test putative small molecule binders identified from the SMM screen.  For each experiment:
**What specifically will the experiment test?
+
**What specifically will the experiment test
 +
**How will this experiment bolster the results from the current research project?
 
**Is the experiment a next step?  Does the experimental approach make assumptions beyond the data acquired from the SMM screen?
 
**Is the experiment a next step?  Does the experimental approach make assumptions beyond the data acquired from the SMM screen?
 
**Include some information regarding a method that could be used to complete the experiment.  What controls should be included?
 
**Include some information regarding a method that could be used to complete the experiment.  What controls should be included?

Revision as of 16:54, 25 July 2020

20.109(F20): Laboratory Fundamentals of Biological Engineering

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Fall 2020 schedule        FYI        Assignments        Homework        Communication |        Accessibility

       M1: Genomic instability        M2: Drug discovery        M3: Metabolic engineering       


Introduction

Protocols

Part X: Design experiments to test putative small molecule binders

In your laboratory notebook, complete the following:

  • Consider aspects of the experimental approach that could be improved.
    • What steps might you do differently to improve the results?
  • Consider two potential next step experiments that you might perform to test putative small molecule binders identified from the SMM screen. For each experiment:
    • What specifically will the experiment test?
    • How will this experiment bolster the results from the current research project?
    • Is the experiment a next step? Does the experimental approach make assumptions beyond the data acquired from the SMM screen?
    • Include some information regarding a method that could be used to complete the experiment. What controls should be included?
  • Consider the implications of your research.
    • How does your research address the knowledge gap / research question? This should tie back to the information provided in the Introduction of your Research article.
    • How does your research advance the field of anti-malarial drug discovery? Don't overreach, but do state what is now known because of your work.

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