20.109(S24):Class data
From Course Wiki
Module 1: Drug discovery
Please find uploaded data for Mod 1 in the Dropbox folder linked here.
Please find the SMM screen results here.
Please find the EMSA results here.
DSF results:
Replicate #1 | Replicate #2 | Replicate #3 | Average Tm | |
TR Orange | ||||
DMSO | 45.57 | 45.57 | 47.10 | 46.08 |
Small molecule #1 | 45.57 | 35.38 | 45.57 | 42.17 |
Small molecule #6 | 44.55 | 46.08 | 45.06 | 45.23 |
Small molecule #9 | 45.06 | 46.59 | 46.08 | 45.91 |
Small molecule #10 | 43.53 | 45.06 | 45.57 | 44.72 |
TR Yellow | ||||
DMSO | 48.12 | 47.61 | 49.13 | 48.29 |
Small molecule #2 | 48.62 | 46.59 | 44.55 | 46.59 |
Small molecule #10 | 47.61 | 47.61 | 47.61 | 47.61 |
Small molecule #11 | 44.55 | 45.57 | 44.55 | 44.89 |
Small molecule #13 | 47.10 | 47.10 | 49.13 | 47.78 |
TR Green | ||||
DMSO | 43.02 | 45.06 | 45.06 | 44.37 |
Small molecule #2 | 43.02 | 47.10 | 45.57 | 45.23 |
Small molecule #6 | 46.08 | 49.65 | 46.08 | 47.27 |
Small molecule #9 | 44.04 | 45.06 | 46.59 | 45.23 |
Small molecule #10 | 46.08 | 45.57 | 48.62 | 46.76 |
TR Blue | ||||
DMSO | 47.11 | 45.08 | 44.06 | 45.42 |
Small molecule #1 | 48.64 | 48.64 | 44.06 | 47.11 |
Small molecule #2 | 46.60 | 47.11 | 43.56 | 45.76 |
Small molecule #4 | 46.60 | 44.57 | 43.56 | 44.91 |
Small molecule #10 | 47.62 | 44.57 | 44.06 | 45.42 |
TR Pink | ||||
DMSO | 47.11 | 44.57 | 44.57 | 45.42 |
Small molecule #1 | 46.10 | 46.60 | 45.08 | 45.93 |
Small molecule #2 | 45.59 | 46.10 | 47.62 | 46.43 |
Small molecule #10 | 47.11 | 44.06 | 45.57 | 45.25 |
Small molecule #11 | 45.08 | 44.06 | 44.06 | 44.40 |
Replicate #1 | Replicate #2 | Replicate #3 | Average Tm | |
WF Red | ||||
DMSO | 47.05 | 44.51 | 35.86 | 42.47 |
Small molecule #3 | 45.53 | 46.55 | 46.04 | 46.04 |
Small molecule #4 | 46.55 | 47.05 | 45.53 | 46.38 |
Small molecule #5 | 43.49 | 47.06 | 46.55 | 45.70 |
Small molecule #8 | 45.02 | 46.55 | 45.53 | 45.70 |
WF Orange | ||||
DMSO | 44.02 | 45.55 | 46.05 | 45.21 |
Small molecule #1 | 43.09 | 46.56 | 46.56 | 45.40 |
Small molecule #2 | 44.53 | 45.04 | 44.53 | 44.77 |
Small molecule #10 | 45.04 | 46.56 | 45.04 | 45.55 |
Small molecule #13 | 46.05 | 44.53 | 44.53 | 45.04 |
WF Yellow | ||||
DMSO | 43.50 | 46.04 | 45.53 | 45.02 |
Small molecule #2 | 44.52 | 46.04 | 45.53 | 45.36 |
Small molecule #10 | 44.52 | 46.04 | 48.59 | 46.38 |
Small molecule #11 | 46.04 | 45.02 | 47.57 | 46.21 |
Small molecule #13 | 44.01 | 43.50 | 45.02 | 44.18 |
WF Green | ||||
DMSO | 45.04 | 43.51 | 43.00 | 43.85 |
Small molecule #2 | 46.05 | 46.05 | 46.56 | 46.22 |
Small molecule #9 | 46.05 | 45.04 | 46.05 | 45.71 |
Small molecule #10 | 45.04 | 45.04 | 45.04 | 45.04 |
Small molecule #13 | 44.53 | 47.07 | 44.54 | 45.38 |
WF Blue | ||||
DMSO | 46.04 | 44.52 | 43.50 | 44.685 |
Small molecule #5 | 45.02 | 43.50 | 45.02 | 45.70 |
Small molecule #9 | 47.06 | 47.06 | 45.02 | 46.38 |
Small molecule #10 | 48.08 | 45.02 | 44.01 | 45.70 |
Small molecule #13 | 45.53 | 43.50 | 44.01 | 44.35 |
WF Pink | ||||
DMSO | 44.01819 | 46.46263 | 45.54488 | 45.3419 |
Small molecule #5 | 46.05378 | 45.03598 | 47.58047 | 46.22341 |
Small molecule #9 | 45.03598 | 46.56268 | 45.54488 | 45.71451 |
Small molecule #10 | 44.01819 | 46.56268 | 44.52709 | 45.0360 |
Small molecule #13 | 44.01819 | 44.52709 | 46.05378 | 44.86635 |
WF Purple | ||||
DMSO | 47.05 | 43.50 | 42.99 | 44.51 |
Small molecule #5 | 45.53 | 47.06 | 45.53 | 46.04 |
Small molecule #9 | 42.98 | 46.04 | 48.59 | 45.87 |
Small molecule #10 | 44.51 | 45.02 | 46.55 | 45.36 |
Small molecule #13 | 46.04 | 43.50 | 46.04 | 45.19 |
Replicate #1 | Replicate #2 | Replicate #3 | Average Tm | |
WF Teal | ||||
DMSO | 45.54 | 45.54 | 43.00 | 44.69 |
Small molecule #1 | 47.07 | 46.05 | 44.53 | 45.88 |
Small molecule #2 | 44.53 | 45.04 | 45.54 | 45.04 |
Small molecule #10 | 46.56 | 46.56 | 47.07 | 46.73 |
Small molecule #11 | 47.07 | 46.56 | 44.53 | 46.05 |
Module 2: Protein engineering
Please find uploaded data for Mod 2 in the Dropbox folder linked [here].
T/R
Team | Peptide sequence | DNA sequence for peptide |
TR orange | DCCDCC | GAC TGT TGC GAT TGT TGC |
TR yellow | CCGCCGCC | TGC TGT GGC TGT TGT GGC TGT TGC |
TR green | CGCGGHGH | TGC GGA TGT GGA GGT CAT GGT CAC |
TR blue | GCCGCCG | GGA TGT TGT GGA TGC TGT GGC |
TR pink | GCHGCH | GGT TGT CAC GGT TGT CAC |
W/F
Team | Peptide sequence | DNA sequence for peptide |
WF red | GHGDGHGD | GGT CAC GGT GAC GGT CAC GGT GAC |
WF orange | CDCCDCCD | TGT GAC TGT TGC GAC TGC TGC GAC |
WF yellow | CGHCGCC | TGT GGT CAT TGT GGT TGT TGT |
WF green | HEHEHE | CAC GAA CAC GAA CAC GAA |
WF blue | PCACACA | CCA TGT GCA TGT GCA TGT GCC |
WF teal | GHHGHH | GGA CAT CAC GGA CAT CAC |
WF pink | GCHDWC | GGA TGT CAT GAT TGG TGC |
WF purple | DCCDCCD | GAC TGT TGC GAT TGC TGT GAC |